KMID : 0370219980420030257
|
|
Yakhak Hoeji 1998 Volume.42 No. 3 p.257 ~ p.264
|
|
Synthesis of Fluorinated New Thebaine Derivatives
|
|
±è±ÙÀç/Kim KJ
±è¼ö¸¸/Kim SM
|
|
Abstract
|
|
|
5-Methylthebaine was obtained by treating thebaine with n-butyllithium and methylfluorosulfonate. Hetero Diels-Alder reaction of thebaine and 5-methylthebaine with trifluoroacet aldehyde afforded 14-beta-(triflu-oro-2-hydroxyethyl)codeine (2) and 14-beta-(trifluoro-2-hydroxyethyl)-5-methylcodeinone (9). 6-alpha-OH compound (4) was obtained by employing CeCl2 and NaBH4. After synthesized a derivative substituted for 3-OH (5), using boron tribromied, We synthesized a new derivative that make double bond in C-7, C-8 into epoxode (6), (10). Through inspecting an influence on structure-activity and analgetic action, we are going to examine which opiold acceptor has a selectivity.
|
|
KEYWORD
|
|
|
|
FullTexts / Linksout information
|
|
|
|
Listed journal information
|
|
|